Eigenh. Manuskript.
Autograph ist nicht mehr verfügbar
Paul Ehrlich (1854–1915), physician and Nobel laureate. AMs. No place or date. 17 pp. 4°. – In German. Rough draft of a lecture “for colleagues and co-students” on immunity research, largely composed of catchwords and sentence fragments. Ehrlich provides an outline of his research, mentioning Svante Arrhenius, Emil von Behring (repeatedly), Jules Bordet, Albert Calmette, Max von Gruber, and Richard Pfeiffer. Several main theorems are developed more fully: I. “There is no such thing as perfect immunity to a toxin” (p. 10). – II: “Receptor deficiency causes tissue immunity, as evidenced by dermal toxins. | The more the toxophoric receptors are localized exclusively on a vital organ, the greater is the sensitivity of urine to a certain toxin | Tetanus in a mouse. | However, if the receptors are not only in the vital organ but also in systems of lesser importance, this produces a certain anergy, cf. diphtheria toxins in rabbits” (p. 11). – III: “[...] I now reach the point in which I differ with Arrhenius. The views at which I have arrived through partial saturation, are based, as I will proceed to demonstrate, on the fact that we must assume at least two different toxins in diphtheria toxin which differ in avidity and effect” (p. 13). – In black ink, written with different pens, and with insertions in blue and red crayon; numbered at the upper edge.